CCP

CCP 56(4), October 2005

• Bruno, et al., "Population pharmacokinetics of trastuzumab in patients With HER2+ metastatic breast cancer"
  • 500 回ブートストラップ．成功回数は記載なし．
  • Posterior predictive check (PPC) を行っている．指標としたパラメータはトラフ濃度の 25%, 50%, 75% 点，平均，標準偏差．

These covariate effects on trastuzumab exposure were modest and not clinically important in comparison with the large inter-patient variability of CL.