Alan Maloney, Mats O. Karlsson, and Ulrika S. H. Simonsson (2007), JCP, "Optimal Adaptive Design in Clinical Drug Development: A Simulation Example"

これでどうにかなるのならそれも本望かと。J

http://springerlink.com/openurl.asp?genre=journal&issn=1573-8744 Simulating pharmacokinetic and pharmacodynamic fuzzy-parameterized models: a comparison of numerical methods Author(s): Kok-Yong Seng, Ivan Nestorov, Paolo Vicini http://dx.d…