SimCYP と OST

新着 論文
  • Dumont C, Mentré F, Gaynor C, Brendel K, Gesson C, Chenel M. (2012) Clin Pharmacokinet, "Optimal Sampling Times for a Drug and its Metabolite using SIMCYP Simulations as Prior Information" (link)
    • タイトルから一瞬思うような衝撃は実はない。

Plasma concentration-time profiles were simulated in children using a PBPK model previously developed with the software SIMCYP(®) for the parent drug and its active metabolite. Data were analysed using non-linear mixed-effect models with the software NONMEM