日本の事例

新着 論文
  • Mayumi Hasegawa, Yasuhiko Imai, Masaki Hiraoka, Kiyomi Ito and Amit Roy (2011) J.PKPD, "Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients" (link)

The exposure–response relationship was characterized using a Generalized Estimating Equation (GEE) logistic regression model, with time-varying actual trough concentrations and ACR20 responder rates over 6 months