AAPS J

• Khandelwal A, Harling K, Jonsson EN, Hooker AC, Karlsson MO (2011) AAPS J, "A Fast Method for Testing Covariates in Population PK/PD Models"

The proposed method is a first-order conditional estimation (FOCE)-based linear approximation of the influence of covariates on the model predictions.

　線形近似の話。今まで出回っていたのは FO-based だったからそれを FOCE にしてみた、と。