J. PKPD

• Elizabeth Y. Shang, Megan A. Gibbs, Jaren W. Landen, Michael Krams, Tanya Russell, Nicholas G. Denman and Diane R. Mould (2009), "Evaluation of structural models to describe the effect of placebo upon the time course of major depressive disorder"

Disease progression modeling is a tool that has been employed for such evaluations and several models have been proposed to describe major depressive disorder. Placebo data from three clinical depression trials were used to evaluate three published models. Each model was used to describe Hamilton Rating Scale for major depression (HAMD) data and results were evaluated.

• • 必読。
  • USD34