J PKPD

• Karin Tunblad, Lindbom, McFadyen, E. Niclas Jonsson, Marshall and Mats O. Karlsson (Online First), "The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic data"

Inclusion and exclusion of covariates using clinical irrelevance was based on reduction in interindividual variability and changes in parameters at the extremes of the covariate distribution.

The pooled data was split in three parts which were used for covariate selection, parameter estimation and evaluation of predictive performance.