CBZ
- Laszlo Tothfalusi, Szilvia Speidl & Laszlo Endrenyi (2007), "Exposure-response analysis reveals that clinically important toxicity difference can exist between bioequivalent carbamazepine tablets"
- id:Fumi:20080620:1213956863
Olling et al. (...) were unable to demonstrate significant relationships between adverse effects and PK metrics. We have also failed, using conventional statistical techniques such as logistic regression. However, a combination of modern exploratory data analysis such as GAM with mixed-effect PK-PD modelling has shown a highly significant relaionships using the results of a relatively small, conventional size BE trial.