Optimal design

• Juliana F Roos, Carl M J Kirkpatrick, Susan E Tett, Andrew J McLachlan, Stephen B Duffull (2008) "Development of a sufficient design for estimation of fluconazole pharmacokinetics in people with HIV infection"

This is the first time that healthy volunteer data (e.g. from Phase I) has been used to develop an optimal design that is to be conducted in a population with different characteristics due to disease (e.g. Phase II).