今日の論文

• Magnusson, Karlsson, and Sandstrom , Pharm Res 23(3): 521-32, 2006, "A Mechanism-Based Integrated Pharmacokinetic Enzyme Model Describing the Time Course and Magnitude of Phenobarbital-Mediated Enzyme Induction in the Rat"

To our knowledge, this is the first example of an induction model that simultaneously describes plasma PK and in vitro data.

• Ng, et al., Pharm Res 23(1): 95-103, 2006, "Pharmacokinetics/Pharmacodynamics of Nondepleting Anti-CD4 Monoclonal Antibody (TRX1) in Healthy Human Volunteers"
  • Simultaneous 解析，と（一応）書いてある．
• Satomi Onoue and Yoshiko Tsuda (Pfizer), Pharm Res 23(1): 156-64, 2006, "Analytical Studies on the Prediction of Photosensitive/Phototoxic Potential of Pharmaceutical Substances"
• Mentre and Escolano, J PK/PD, Online First, "Prediction Discrepancies for the Evaluation of Nonlinear Mixed-Effects Models"